Relationship between electrode position of deep brain stimulation and motor symptoms of Parkinson’s disease

Abstract Background To investigate the relationship between position of bilateral STN-DBS location active contacts and clinical efficacy on motor symptoms in Parkinson’s disease (PD) patients. Methods Retrospectively analyze data 57 patients with PD who underwent from March 2018 to December 2018. Unified Disease Rating Scale-Part III (UPDRS-III) score, levodopa equivalent day dose (LEDD), Quality Life Scale (PDQ-39) before operation within 6 months after operation, determine activated volume tissue (VTA) Montreal Neurological Institute (MNI) space, their correlation improvement rate (UPDRS-III score rate). Results After follow up, UPDRS-III scores (Med-off) were improved by 55.4 ± 18.9% ( P <0.001) compared that operation. The PDQ-39 [(47.4 23.2)%, < 0.001)] reduction LEDD [(40.1 24.3)%, 0.01)] at postoperation positively correlated (Med-off)(PDQ-39: r = 0.461, <0.001; LEDD: 0.354, 0.007), Z-axis coordinate contact MNI space (left side: 0.349, 0.008;right 0.369, 0.005). In there was no VTA STN subregion, associative subregion limbic electrode (all > 0.05). At surgery, difference different subgroups(<25, 25 50%, and>50%) statistically significant 0.030; right 0.024). groups Conclusion can improve quality life. closer stimulation is dorsolateral sensorimotor area, higher DBS